EBO-PEP

Protecting high-risk contacts from developing Ebola Virus Disease (EVD)

About the project

The EBO-PEP project aims to strengthen the response capacity against Ebola Virus Disease by evaluating the effectiveness of a post-exposure prophylaxis (PEP) strategy among individuals identified as high-risk contacts.
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The EBO-PEP project will

1

Conduct a multicenter, multi-epidemic Phase III clinical trial across several African countries to assess the efficacy of a monoclonal antibody (mAbs) therapy used in combination with vaccination, administered as PEP for high-risk contacts of EVD cases.

2

Strengthen the capacity of clinical researchers, while increasing knowledge and community engagement in Ebola research and medical response.

3

Define the optimal PEP strategy for high-risk contacts and advocate for its implementation in countries affected by EVD outbreaks.
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Map

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The project will be deployed during an EVD outbreak, as close as possible to active transmission zones. To achieve this, the EBO-PEP team will coordinate with national outbreak response operations in countries where Ebola is most likely to re-emerge, including the Democratic Republic of the Congo (DRC), Guinea, Sierra Leone, and/or Liberia, with support from ALIMA and MSF. Additional countries may be included depending on future outbreak locations.

Key figures

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Number of known Ebola virus strains 1

0

Number of countries with at least one reported case of Ebola*. 2

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Number of Ebola* epidemics worldwide since 1976 3
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Number of people who have died from Ebola* since its discovery in 1976 3, 4

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Number of people infected with Ebola* since its discovery in 1976 3, 4

*All strains combined

The Consortium

  1. World Health Organization. Maladie à virus Ebola [Internet]. Genève : WHO; 2025 [cité 2025 Nov 27]. Available at : https://www.who.int/fr/news‑room/fact‑sheets/detail/ebola‑disease
  2. Mercy Corps. African countries fighting Ebola outbreaks [Internet]. Mercy Corps; 2019 [cité 2025 Nov 27]. Available at : https://www.mercycorps.org/blog/ebola-outbreaks-africa-guide/chapter-3
  3. Centers for Disease Control and Prevention. Ebola (Ebola virus disease) — Outbreaks [Internet]. Atlanta (GA) : CDC; [cité 2025 Nov 27]. Available at : https://www.cdc.gov/ebola/outbreaks/index.html
  4. Barbiero VK. Ebola: A Hyperinflated Emergency. Glob Health Sci Pract. 2020 Jun 30;8(2):178-182. DOI: 10.9745/GHSP-D-19-00422. PMID: 32430358; PMCID: PMC7326525.

Funders

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global-health

This project 101145675 – EBO-PEP – HORIZON-JU-GHEDCTP3-2023-01 is supported by the Global Health EDCTP3 partnership.